Endocrine Abstracts

Antithyroid drugs represent mainly the first choice therapy in hyperthyroid Graves’ disease. Their therapeutical ineffectiveness can lead to the onset or the severity of ophthalmopathy associated with Graves’ disease. Type 2 5’-deiodinase enzyme (DIO2) plays a crucial role besides type 1 5’-deiodinase enzyme in the development of Graves’ hyperthyroidism. Anti-thyroid drugs inhibit the activity of both type 5’-deiodinases blocking the synthesis of ...